Thesis icon

Thesis

The role of YAP and cell of origin during the progression of pancreatic neoplastic lesions to invasive ductal adenocarcinoma

Abstract:

Pancreatic ductal adenocarcinoma (PDAC) is considered one of the most fatal cancer types with a very low survival rate. The development of dysplasia in normal ductal epithelium is the initiating step of the disease, which then undergoes multiple grades of pancreatic intraepithelial neoplasia (PanIN) lesions before developing into invasive adenocarcinoma. KRAS mutations occur during early stages of malignant transformation and act as a critical event in both initiating and maintaining PDAC ...

Expand abstract

Actions


Access Document


Files:

Authors


More by this author
Division:
MSD
Department:
Oncology
Role:
Author

Contributors

Role:
Supervisor
More from this funder
Name:
Pancreatic Cancer UK
Funder identifier:
http://dx.doi.org/10.13039/100009795
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP