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Preacinetobactin not acinetobactin is essential for iron uptake by the BauA transporter of the pathogen Acinetobacter baumannii

Abstract:

New strategies are urgently required to develop antibiotics. The siderophore uptake system has attracted considerable attention, but rational design of siderophore antibiotic conjugates requires knowledge of recognition by the cognate outer-membrane transporter. Acinetobacter baumannii is a serious pathogen, which utilizes (pre)acinetobactin to scavenge iron from the host. We report the structure of the (pre)acinetobactin transporter BauA bound to the siderophore, identifying the structural d...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/eLife.42270

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Structural Biology
Role:
Author
ORCID:
0000-0002-4097-4331
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Role:
Author
ORCID:
0000-0002-0228-6394
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Publisher:
eLife Sciences Publisher's website
Journal:
eLife Journal website
Volume:
7
Pages:
e42270
Publication date:
2018-12-18
Acceptance date:
2018-12-02
DOI:
EISSN:
2050-084X
Pmid:
30558715
Source identifiers:
954553
Language:
English
Keywords:
Pubs id:
pubs:954553
UUID:
uuid:a9fd81c4-f5d5-4434-9915-c2396c85ea71
Local pid:
pubs:954553
Deposit date:
2019-01-08

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