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Ghrelin's role as a major regulator of appetite and its other functions in neuroendocrinology.

Abstract:

Ghrelin is a circulating growth-hormone-releasing and appetite-inducing brain-gut peptide. It is a known natural ligand of the growth hormone secretagogue receptor (GHS-R). Ghrelin is acylated on its serine 3 residue by ghrelin O-acyltransferase (GOAT). The acylation is essential for its orexigenic and adipogenic effects. Ghrelin exerts its central orexigenic effect through activation of various hypothalamic and brain stem neurons. Several new intracellular targets/mediators of the appetite-i...

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Publication status:
Published

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Journal:
Progress in brain research More from this journal
Volume:
182
Pages:
189-205
Publication date:
2010-01-01
DOI:
EISSN:
1875-7855
ISSN:
0079-6123
Language:
English
Keywords:
Pubs id:
pubs:138249
UUID:
uuid:a9fbf1b4-1ae5-44e7-b3ef-59dfb7d427f7
Local pid:
pubs:138249
Source identifiers:
138249
Deposit date:
2012-12-19

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