Ghrelin's role as a major regulator of appetite and its other functions in neuroendocrinology.

Journal article

Ghrelin is a circulating growth-hormone-releasing and appetite-inducing brain-gut peptide. It is a known natural ligand of the growth hormone secretagogue receptor (GHS-R). Ghrelin is acylated on its serine 3 residue by ghrelin O-acyltransferase (GOAT). The acylation is essential for its orexigenic and adipogenic effects. Ghrelin exerts its central orexigenic effect through activation of various hypothalamic and brain stem neurons. Several new intracellular targets/mediators of the appetite-i...

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Authors: Lim, C; Kola, B; Korbonits, M; Grossman, AB

• Publication status: Published
• Journal: Progress in brain research
• Volume: 182
• Pages: 189-205
• Publication date: 2010-01-01
• DOI: 10.1016/s0079-6123(10)82008-4
• EISSN: 1875-7855
• ISSN: 0079-6123
• Language: English
• Keywords: Signal Transduction; Humans; Neuroendocrinology; Ghrelin; Animals; Appetite; Pituitary Gland, Anterior; Diabetes Mellitus, Type 2; Obesity; Anorexia; Receptors, Ghrelin; Pituitary Neoplasms