Journal article icon

Journal article

Outcome of Down syndrome associated acute lymphoblastic leukaemia treated on a contemporary protocol

Abstract:

We report the outcome for children and young people with Down syndrome-associated acute lymphoblastic leukaemia (DS-ALL) treated on a contemporary protocol. Compared with non-DS ALL, patients with DS-ALL had an inferior event-free survival (65·6% vs. 87·7% at 5 years; P < 0·00005) and overall survival (70·0% vs. 92·2%; P < 0·00005). Excess treatment-related mortality - was primarily responsible for the worse outcomes for DS-ALL (21·6% at 5 years, vs. 3·3%, P < 0·00005). Minimal resid...

Expand abstract

Actions


Access Document


Publisher copy:
10.1111/bjh.12739

Authors


Patrick, K More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit
Goulden, N More by this author
Rowntree, C More by this author
Expand authors...
Publisher:
Blackwell Publishing Ltd
Journal:
British Journal of Haematology
Volume:
165
Issue:
4
Pages:
552-555
Publication date:
2014
DOI:
EISSN:
1365-2141
ISSN:
0007-1048
URN:
uuid:a9f75ac7-ee76-4ef7-91e2-df0ba8e9af57
Source identifiers:
464809
Local pid:
pubs:464809
Language:
English
Keywords:

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP