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Thesis

Development of bisulfite-free DNA methylation sequencing methods and their application to cell-free DNA for cancer detection

Abstract:

5-Methylcytosine (5mC) is the most abundant epigenetic mark in DNA regulating gene expression and influencing crucial cellular processes. Aberrant DNA methylation is involved in pathogenesis of human malignancies. Detection of cancer-specific methylation patterns in cell-free DNA (cfDNA) is a promising approach for development of minimally invasive, liquid biopsy assays. Most of methylation sequencing methods are based on bisulfite treatment that causes an extensive DNA damage, therefore a...

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Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Research group:
Chunxiao Song
Oxford college:
Kellogg College
Role:
Author
ORCID:
0000-0003-3284-6249

Contributors

Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Oxford college:
Kellogg College
Role:
Supervisor
ORCID:
0000-0002-2273-5994
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Oxford college:
Kellogg College
Role:
Supervisor
More from this funder
Name:
Ludwig Institute for Cancer Research
Funder identifier:
http://dx.doi.org/10.13039/501100000289
Funding agency for:
Siejka-Zielinska, P
Programme:
Ludwig studentship
More from this funder
Name:
Cancer Research UK
Funding agency for:
Song, C
Grant:
C63763/A26394
C63763/A27122
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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