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Naïve-pooled pharmacokinetic analysis of pyrazinamide, isoniazid and rifampicin in plasma and cerebrospinal fluid of Vietnamese children with tuberculous meningitis

Abstract:

Among the various forms of TB, tuberculous meningitis (TBM) is the most severe, with about 30 % mortality and 50 % of survivors left with neurological sequelae. Children suffer more frequently from TBM than adults and outcomes are often poor due to difficulties in making the diagnosis and uncertainty regarding the best anti-tuberculosis drug regimen. The aim of this prospective study was to describe the pharmacokinetics of pyrazinamide, isoniazid and rifampicin in plasma and cerebrospinal ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12879-016-1470-x

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
Publisher:
BioMed Central
Journal:
BMC Infectious Diseases More from this journal
Volume:
16
Article number:
144
Publication date:
2016-04-02
Acceptance date:
2016-03-14
DOI:
ISSN:
1471-2334
Keywords:
Pubs id:
pubs:612713
UUID:
uuid:a9ee7425-e797-482a-8c8c-50ba931801aa
Local pid:
pubs:612713
Source identifiers:
612713
Deposit date:
2016-04-01

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