- Abstract:
-
Iron overload may contribute to the risk of Alzheimer's disease (AD). In the Epistasis Project, with 1757 cases of AD and 6295 controls, we studied 4 variants in 2 genes of iron metabolism: hemochromatosis (HFE) C282Y and H63D, and transferrin (TF) C2 and -2G/A. We replicated the reported interaction between HFE 282Y and TF C2 in the risk of AD: synergy factor, 1.75 (95% confidence interval, 1.1-2.8, p = 0.02) in Northern Europeans. The synergy factor was 3.1 (1.4-6.9; 0.007) in subjects with...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.neurobiolaging.2010.07.018
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- Journal:
- Neurobiology of aging
- Volume:
- 33
- Issue:
- 1
- Pages:
- 202.e1-202.13
- Publication date:
- 2012-01-05
- DOI:
- EISSN:
-
1558-1497
- ISSN:
-
0197-4580
- URN:
-
uuid:a9ec9984-71b9-4ece-9685-fa2397a3c64e
- Source identifiers:
-
71161
- Local pid:
- pubs:71161
- Copyright date:
- 2012
Journal article
Transferrin and HFE genes interact in Alzheimer's disease risk: the Epistasis Project.
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