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Transferrin and HFE genes interact in Alzheimer's disease risk: the Epistasis Project.

Abstract:

Iron overload may contribute to the risk of Alzheimer's disease (AD). In the Epistasis Project, with 1757 cases of AD and 6295 controls, we studied 4 variants in 2 genes of iron metabolism: hemochromatosis (HFE) C282Y and H63D, and transferrin (TF) C2 and -2G/A. We replicated the reported interaction between HFE 282Y and TF C2 in the risk of AD: synergy factor, 1.75 (95% confidence interval, 1.1-2.8, p = 0.02) in Northern Europeans. The synergy factor was 3.1 (1.4-6.9; 0.007) in subjects with...

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Publication status:
Published

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Journal:
Neurobiology of aging
Volume:
33
Issue:
1
Pages:
202.e1-202.13
Publication date:
2012-01-05
DOI:
EISSN:
1558-1497
ISSN:
0197-4580
URN:
uuid:a9ec9984-71b9-4ece-9685-fa2397a3c64e
Source identifiers:
71161
Local pid:
pubs:71161

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