The clinical benefit of adjunctive dexamethasone in tuberculous meningitis is not associated with measurable attenuation of peripheral or local immune responses.

Journal article

Outcome from tuberculous meningitis (TBM) is believed to be dependent on the severity of the intracerebral inflammatory response. We have recently shown that dexamethasone improved survival in adults with TBM and postulated that the clinical effect would be associated with a measurable systemic and intracerebral impact on immunological markers of inflammation. Prolonged inflammatory responses were detected in all TBM patients irrespective of treatment assignment (placebo or dexamethasone). Th...

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Authors: Simmons, C; Thwaites, G; Quyen, N; Chau, T; Mai, P

• Publication status: Published
• Journal: Journal of Immunology
• Volume: 175
• Issue: 1
• Pages: 579-590
• Publication date: 2005-07-01
• DOI: 10.4049/jimmunol.175.1.579
• EISSN: 1550-6606
• ISSN: 0022-1767
• Language: English
• Keywords: Female; Double-Blind Method; Adolescent; Dexamethasone; Chemotherapy, Adjuvant; Tuberculosis, Meningeal; Lymphocyte Subsets; Middle Aged; Adult; Male; Interferon-gamma; Aged; Cytokines; Mycobacterium tuberculosis; Humans; Anti-Inflammatory Agents; Antigens, Bacterial; Chemokines