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Molecular footprints reveal the impact of the protective HLA-A*03 allele in hepatitis C virus infection

Abstract:

Background and aims: CD8 T cells are central to the control of hepatitis C virus (HCV) although the key features of a successful CD8 T cell response remain to be defined. In a cohort of Irish women infected by a single source, a strong association between viral clearance and the human lecucocyte (HLA)-A*03 allele has been described, and the aim of this study was to define the protective nature of the associated CD8 T cell response. Methods: A sequence-led approach was used to identify HLA-A*0...

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Publisher copy:
10.1136/gut.2010.228403

Authors


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Journal:
Gut
Volume:
60
Issue:
11
Pages:
1563-1571
Publication date:
2011-11-05
DOI:
EISSN:
1468-3288
ISSN:
0017-5749
URN:
uuid:a9e0bb3b-7f51-4a4b-9122-958021745935
Source identifiers:
192902
Local pid:
pubs:192902
Language:
English

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