- Abstract:
-
Background and aims: CD8 T cells are central to the control of hepatitis C virus (HCV) although the key features of a successful CD8 T cell response remain to be defined. In a cohort of Irish women infected by a single source, a strong association between viral clearance and the human lecucocyte (HLA)-A*03 allele has been described, and the aim of this study was to define the protective nature of the associated CD8 T cell response. Methods: A sequence-led approach was used to identify HLA-A*0...
Expand abstract - Publisher copy:
- 10.1136/gut.2010.228403
-
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- Journal:
- Gut
- Volume:
- 60
- Issue:
- 11
- Pages:
- 1563-1571
- Publication date:
- 2011-11-05
- DOI:
- EISSN:
-
1468-3288
- ISSN:
-
0017-5749
- URN:
-
uuid:a9e0bb3b-7f51-4a4b-9122-958021745935
- Source identifiers:
-
192902
- Local pid:
- pubs:192902
- Language:
- English
- Copyright date:
- 2011
Journal article
Molecular footprints reveal the impact of the protective HLA-A*03 allele in hepatitis C virus infection
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