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Separation of monoclonal antibody alemtuzumab monomer and dimers using ultrafiltration.

Abstract:

This article examines the feasibility of using ultrafiltration to separate the monomer of the monoclonal antibody alemtuzumab (Campath or Campath-1H) from a mixture of dimer and higher-order oligomers (collectively called "dimers" here). Using parameter scanning ultrafiltration, we initially assessed the suitability of the following membranes: 100 kDa and 300 kDa polyethersulfone (PES) membranes, and a 100 kDa polyvinylidene fluoride (PVDF) membrane. A detailed study was then carried out to e...

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Publication status:
Published

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Publisher copy:
10.1002/bit.20416

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Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Role:
Author
Journal:
Biotechnology and bioengineering More from this journal
Volume:
90
Issue:
4
Pages:
422-432
Publication date:
2005-05-01
DOI:
EISSN:
1097-0290
ISSN:
0006-3592
Language:
English
Keywords:
Pubs id:
pubs:61897
UUID:
uuid:a9df08e1-0911-49b1-bad3-d9303fdd8c1c
Local pid:
pubs:61897
Source identifiers:
61897
Deposit date:
2013-11-17

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