Journal article icon

Journal article

Sjögren syndrome/scleroderma autoantigen 1 is a direct Tankyrase binding partner in cancer cells

Abstract:

Sjögren syndrome/scleroderma autoantigen 1 (SSSCA1) was first described as an auto-antigen over-expressed in Sjögren's syndrome and in scleroderma patients. SSSCA1 has been linked to mitosis and centromere association and as a potential marker candidate in diverse solid cancers. Here we characterize SSSCA1 for the first time, to our knowledge, at the molecular, structural and subcellular level. We have determined the crystal structure of a zinc finger fold, a zinc ribbon domain type 2 (ZNRD2)...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1038/s42003-020-0851-2

Authors


More by this author
Role:
Author
ORCID:
0000-0002-9254-0690
Publisher:
Springer Nature
Journal:
Communications Biology More from this journal
Volume:
3
Issue:
2020
Article number:
123
Publication date:
2020-03-13
Acceptance date:
2020-02-21
DOI:
EISSN:
2399-3642
Pmid:
32170109
Language:
English
Keywords:
Pubs id:
1095608
Local pid:
pubs:1095608
Deposit date:
2020-03-25

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP