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Journal article

IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma

Abstract:

Treatment with immune checkpoint blockade (ICB) frequently triggers immune-related adverse events (irAEs), causing considerable morbidity. In 214 patients receiving ICB for melanoma, we observed increased severe irAE risk in minor allele carriers of rs16906115, intronic to IL7. We found that rs16906115 forms a B cell-specific expression quantitative trait locus (eQTL) to IL7 in patients. Patients carrying the risk allele demonstrate increased pre-treatment ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41591-022-02095-5

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Role:
Author
ORCID:
0000-0002-1635-4167
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Role:
Author
ORCID:
0000-0002-0659-5944
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Role:
Author
ORCID:
0000-0002-8983-0355
Publisher:
Springer Nature
Journal:
Nature Medicine More from this journal
Volume:
28
Pages:
2592-2600
Publication date:
2022-12-16
Acceptance date:
2022-10-18
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
Pmid:
36526722
Language:
English
Keywords:
Pubs id:
1316329
Local pid:
pubs:1316329
Deposit date:
2023-01-24

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