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Journal article

Strategies for antigen choice and priming of dendritic cells influence the polarization and efficacy of antitumor T-cell responses in dendritic cell-based cancer vaccination.

Abstract:

Dendritic cells (DCs) primed with tumor antigens (Ags) can stimulate tumor rejection. This study was aimed at evaluating the polarization of T-cell responses using various DC Ag-priming strategies for vaccination purposes. DCs cocultured with irradiated "apoptotic" tumor cells, DC-tumor fusions, and DCs pulsed with freeze-thaw tumor lysate Ags served as Ag-primed DCs, with EG7 tumor cells (class II negative) expressing OVA as the model Ag. DCs loaded with class I- and class II-restricted OVA ...

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Publication status:
Published

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Publisher copy:
10.1007/s00262-004-0542-8

Authors


Galea-Lauri, J More by this author
Darling, D More by this author
Harrison, P More by this author
Farzaneh, F More by this author
Journal:
Cancer immunology, immunotherapy : CII
Volume:
53
Issue:
11
Pages:
963-977
Publication date:
2004-11-05
DOI:
EISSN:
1432-0851
ISSN:
0340-7004
URN:
uuid:a9cbb95e-e6ff-4a18-8405-1a63507c21fc
Source identifiers:
466387
Local pid:
pubs:466387

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