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Farnesyltransferase inhibitors potentiate the antitumor effect of radiation on a human tumor xenograft expressing activated HRAS.

Abstract:

Successful radiosensitization requires that tumor cells become more radiosensitive without causing an equivalent reduction in the survival of cells of the surrounding normal tissues. Since tumor cell radiosensitivity can be influenced by RAS oncogene activation, we have hypothesized that inhibition of oncogenic RAS activity would lead to radiosensitization of tumors with activated RAS. We previously showed in tissue culture that prenyltransferase treatment of cells with activated RAS resulted...

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Publication status:
Published

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Authors


Cohen-Jonathan, E More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Gillies McKenna, W More by this author
Cerniglia, G More by this author
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Volume:
154
Issue:
2
Pages:
125-132
Publication date:
2000-08-05
DOI:
EISSN:
1938-5404
ISSN:
0033-7587
URN:
uuid:a9ca26c5-9131-4ede-95ea-b924a06db2e5
Source identifiers:
117558
Local pid:
pubs:117558

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