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A positive feedback loop drives centrosome maturation in flies

Abstract:

Centrosomes are formed when mother centrioles recruit pericentriolar material (PCM) around themselves. The PCM expands dramatically as cells prepare to enter mitosis (a process termed centrosome maturation), but it is unclear how this expansion is achieved. In flies, Spd-2 and Cnn form an extensive scaffold around the mother centriole that recruits other components of the mitotic PCM, and the Polo-dependent phosphorylation of Cnn at the centrosome is crucial for scaffold assembly. Here we sho...

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Publication status:
Not Published
Peer review status:
Not peer reviewed
Version:
Author's Original

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Publisher copy:
10.1101/380907

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
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Publisher:
ColdSpring Habor Laboratory Publisher's website
Journal:
bioRxiv Journal website
Publication date:
2018-07-31
DOI:
Pubs id:
pubs:923196
URN:
uri:a9c74bf2-9308-4f56-81f4-e72856cacf90
UUID:
uuid:a9c74bf2-9308-4f56-81f4-e72856cacf90
Local pid:
pubs:923196
Keywords:

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