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Elevated CD54 expression renders CD4+ T cells susceptible to NK cell-mediated killing.

Abstract:

A decreased number of CD4+ T cells is a major feature of HIV infection. Here we detected high CD54 expression on CD4+ T cells in HIV-infected individuals, and demonstrate that upregulated CD54 is associated with disease progression in individuals infected with HIV. We also show that CD54 expression leads to the killing of CD4+ T cells by NK cells in vitro, and that this is modulated by NF-κB/p65 signaling. Further, we demonstrate that metformin can suppress CD54 expression on CD4+ T cells by ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1093/infdis/jiz413

Authors


Publisher:
Oxford University Press
Journal:
Journal of Infectious Diseases More from this journal
Volume:
220
Issue:
12
Pages:
1892-1903
Publication date:
2019-08-21
Acceptance date:
2019-08-21
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
Pmid:
31433832
Language:
English
Keywords:
Pubs id:
pubs:1046996
UUID:
uuid:a9c6b5f6-9f60-4119-8e04-7a0eafd77bc6
Local pid:
pubs:1046996
Source identifiers:
1046996
Deposit date:
2019-11-10

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