New blood pressure-associated loci identified in meta-analyses of 475 000 individuals

Journal article

Genome-wide association studies have recently identified >400 loci that harbor DNA sequence variants that influence blood pressure (BP). Our earlier studies identified and validated 56 single nucleotide variants (SNVs) associated with BP from meta-analyses of exome chip genotype data. An additional 100 variants yielded suggestive evidence of association.Here, we augment the sample with 140 886 European individuals from the UK Biobank, in whom 77 of the 100 suggestive SNVs were available fo...

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Authors: Kraja, A; Cook, J; Warren, H; Ferreira, T; Mahajan, A

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: American Heart Association Publisher's website
• Journal: Circulation. Cardiovascular genetics Journal website
• Volume: 10
• Issue: 5
• Pages: 1-53
• Publication date: 2017-10-13
• Acceptance date: 2017-08-17
• DOI: 10.1161/circgenetics.117.001778
• EISSN: 1942-3268
• ISSN: 1942-325X
• Pmid: 29030403
• Language: English
• Keywords: CHARGE EXOME BP, CHD Exome+, Exome BP, GoT2D:T2DGenes Consortia, The UK Biobank Cardio-Metabolic Traits Consortium Blood Pressure Working Group†; Understanding Society Scientific Group