Prognostic significance of a novel hypoxia-regulated marker, carbonic anhydrase IX, in invasive breast carcinoma.

Journal article

PURPOSE: To assess the frequency of expression and the prognostic significance of a hypoxia-regulated marker, carbonic anhydrase IX (CA IX), in a cohort of patients with invasive breast cancer. PATIENTS AND METHODS: CA IX expression was evaluated by immunohistochemistry with a murine monoclonal antibody, M75, in a series of 103 women treated surgically for invasive breast cancer. The majority of patients were treated with adjuvant hormonal or chemotherapy. The frequency of CA IX expression, i...

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Authors: Chia, S; Wykoff, C; Watson, P; Han, C; Leek, R

• Publication status: Published
• Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology
• Volume: 19
• Issue: 16
• Pages: 3660-3668
• Publication date: 2001-08-01
• EISSN: 1527-7755
• ISSN: 0732-183X
• Language: English
• Keywords: Disease-Free Survival; Antibodies, Monoclonal; Adult; Cell Hypoxia; Neoplasm Proteins; Breast Neoplasms; Predictive Value of Tests; Carcinoma, Ductal, Breast; Cohort Studies; Aged; Carbonic Anhydrases; Tumor Markers, Biological; Mice; Antigens, Neoplasm; Survival Analysis; Animals; England; Immunohistochemistry; Humans; Aged, 80 and over; Female; Middle Aged