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Journal article

Statins and oxidative stress in the cardiovascular system

Abstract:

Statins are widely established as an important class of medications for primary and secondary prevention of cardiovascular disease. In addition to their lipid-lowering effects, mounting evidence suggests that statins exhibit non-lipid-lowering mediated effects in the cardiovascular system. These so called “pleiotropic” effects are partly due to antioxidant properties of statins. These are mediated by inhibition of the mevalonate pathway, which interferes with small GTP-ase protein prenylation...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.2174/1381612823666170926130338

Authors


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Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
More by this author
Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
More by this author
Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
Publisher:
Bentham Science Publishers Publisher's website
Journal:
Current Pharmaceutical Design Journal website
Volume:
23
Issue:
46
Pages:
7040 - 7047
Publication date:
2017-09-26
Acceptance date:
2017-09-24
DOI:
EISSN:
1873-4286
ISSN:
1381-6128
Pubs id:
pubs:731199
URN:
uri:a9a49e4b-66e5-42a4-ab73-e39a2ba0d73e
UUID:
uuid:a9a49e4b-66e5-42a4-ab73-e39a2ba0d73e
Local pid:
pubs:731199

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