- Abstract:
-
Statins are widely established as an important class of medications for primary and secondary prevention of cardiovascular disease. In addition to their lipid-lowering effects, mounting evidence suggests that statins exhibit non-lipid-lowering mediated effects in the cardiovascular system. These so called “pleiotropic” effects are partly due to antioxidant properties of statins. These are mediated by inhibition of the mevalonate pathway, which interferes with small GTP-ase protein prenylation...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted manuscript
- Files:
-
-
(pdf, 627.5kb)
-
- Publisher copy:
- 10.2174/1381612823666170926130338
-
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- Publisher:
- Bentham Science Publishers Publisher's website
- Journal:
- Current Pharmaceutical Design Journal website
- Volume:
- 23
- Issue:
- 46
- Pages:
- 7040 - 7047
- Publication date:
- 2017-09-26
- Acceptance date:
- 2017-09-24
- DOI:
- EISSN:
-
1873-4286
- ISSN:
-
1381-6128
- Pubs id:
-
pubs:731199
- URN:
-
uri:a9a49e4b-66e5-42a4-ab73-e39a2ba0d73e
- UUID:
-
uuid:a9a49e4b-66e5-42a4-ab73-e39a2ba0d73e
- Local pid:
- pubs:731199
- Copyright holder:
- Bentham Science Publishers
- Copyright date:
- 2017
- Notes:
- © 2017 Bentham Science Publishers. This is the accepted manuscript version of the article. The final version is available online from Bentham Science Publishers at: https://doi.org/10.2174/1381612823666170926130338
Journal article
Statins and oxidative stress in the cardiovascular system
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