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Different mechanisms underlie the long‐term regulation of pyruvate dehydrogenase kinase (PDHK) by tri‐iodothyronine in heart and liver

Abstract:

Antibodies to purified recombinant PDHKII were used for ELISAs of PDHKII in mitochondrial extracts. In liver, hyperthyroidism elicited a 2.3‐fold increase in PDHK activity (P<0.01) which was accompanied by a significant 1.5‐fold (P<0.001) increase in the amount of mitochondrial immunoreactive PDHKII. In contrast, despite a stable 2.0‐fold increase in cardiac PDHK activity (P<0.001), the amount of mitochondrial immunoreactive PDHKII in heart was unaffected by hyperthyroidism. The mech...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Publisher:
Wiley
Journal:
FEBS Letters More from this journal
Volume:
419
Issue:
1
Pages:
55-57
Publication date:
1997-12-08
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
Keywords:
Pubs id:
pubs:673833
UUID:
uuid:a9a19c94-c30c-402e-8dd5-2cbc5fa47adf
Local pid:
pubs:673833
Source identifiers:
673833
Deposit date:
2017-01-30

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