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The developmental regulation of the human zeta-globin gene in transgenic mice employing beta-galactosidase as a reporter gene.

Abstract:

We have investigated the developmental and tissue specific expression of the human embryonic zeta-globin gene in transgenic mice. A construct containing 550 bp of zeta-globin 5' flanking region, fused to a beta-galactosidase (lacZ) reporter gene and linked to the locus control region (LCR)-like alpha positive regulatory element (alpha PRE) was employed for the production of transgenic mice. Firstly, we compared the number of live born transgenic mice containing this construct to the number of...

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Publication status:
Published

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Publisher copy:
10.1093/nar/20.21.5655

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Nucleic acids research More from this journal
Volume:
20
Issue:
21
Pages:
5655-5660
Publication date:
1992-11-01
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Language:
English
Keywords:
Pubs id:
pubs:11840
UUID:
uuid:a99a882f-dc04-44ca-be10-05ba99d4c863
Local pid:
pubs:11840
Source identifiers:
11840
Deposit date:
2012-12-19

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