- Abstract:
-
Human lymphopoiesis is a dynamic life-long process that starts in utero 6 weeks post-conception. Fetal B-lymphopoiesis remains poorly defined and yet is key to understanding leukemia initiation in early life. Here, we provide a comprehensive analysis of the human fetal B-cell developmental hierarchy. We report the presence in fetal tissues of two distinct CD19+ B-progenitors, an adult-type CD10+ve ProB-progenitor and a new CD10-ve PreProB-progenitor, and describe their molecular and functiona...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Files:
-
-
(pdf)
-
- Publisher copy:
- 10.1182/blood.2019001289
-
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- Publisher:
- American Society of Hematology Publisher's website
- Journal:
- Blood Journal website
- Volume:
- 134
- Issue:
- 13
- Pages:
- 1059–1071
- Publication date:
- 2019-08-05
- Acceptance date:
- 2019-07-05
- DOI:
- EISSN:
-
1528-0020
- ISSN:
-
0006-4971
- Pmid:
-
31383639
- Pubs id:
-
pubs:1039436
- UUID:
-
uuid:a9998bb6-ad5f-45de-89ec-c5b0a8899236
- Source identifiers:
-
1039436
- Local pid:
- pubs:1039436
- Language:
- English
- Copyright holder:
- ASH
- Copyright date:
- 2019
- Rights statement:
- © 2019 American Society of Hematology
- Notes:
- This is the accepted manuscript version of the article. The final version is available from American Society of Hematology at: https://doi.org/10.1182/blood.2019001289
Journal article
Discovery of a CD10 negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs
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