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Discovery of a CD10 negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs

Abstract:

Human lymphopoiesis is a dynamic life-long process that starts in utero 6 weeks post-conception. Fetal B-lymphopoiesis remains poorly defined and yet is key to understanding leukemia initiation in early life. Here, we provide a comprehensive analysis of the human fetal B-cell developmental hierarchy. We report the presence in fetal tissues of two distinct CD19+ B-progenitors, an adult-type CD10+ve ProB-progenitor and a new CD10-ve PreProB-progenitor, and describe their molecular and functiona...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1182/blood.2019001289

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Institution:
University of Oxford
Department:
Paediatrics
Role:
Author
ORCID:
0000-0002-3116-1646
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Institution:
University of Oxford
Department:
Paediatrics
Role:
Author
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Institution:
University of Oxford
Department:
RDM
Role:
Author
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Institution:
University of Oxford
Department:
Tropical Medicine
Role:
Author
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Institution:
University of Oxford
Department:
Paediatrics
Role:
Author
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Publisher:
American Society of Hematology Publisher's website
Journal:
Blood Journal website
Volume:
134
Issue:
13
Pages:
1059–1071
Publication date:
2019-08-05
Acceptance date:
2019-07-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
Pmid:
31383639
Pubs id:
pubs:1039436
UUID:
uuid:a9998bb6-ad5f-45de-89ec-c5b0a8899236
Source identifiers:
1039436
Local pid:
pubs:1039436
Language:
English

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