Pathogenetic relevance of HLA class II expressing thyroid follicular cells in nontoxic Goiter and in Graves' disease.

Journal article

HLA class II expressing thyroid follicular cells are found not only in classical thyroid autoimmune diseases, such as Graves' disease, but also in presumably nonautoimmune thyroid disorders such as nontoxic goiter. In this study the immunostimulatory function of the HLA class II expressing thyroid follicular cells derived from patients with nontoxic goiter and with Graves' disease was compared by assessing their capacity to stimulate allogeneic and autologous peripheral blood mononuclear cell...

Expand abstract

Authors: Grubeck-Loebenstein, B; Londei, M; Greenall, C; Pirich, K; Kassal, H

• Publication status: Published
• Journal: Journal of clinical investigation
• Volume: 81
• Issue: 5
• Pages: 1608-1614
• Publication date: 1988-05-01
• DOI: 10.1172/jci113495
• EISSN: 1558-8238
• ISSN: 0021-9738
• Language: English
• Keywords: Cell Line; HLA-D Antigens; Goiter; Graves Disease; Macrophages; Aged; Thyroid Gland; Humans; Aged, 80 and over; Adult; Leukocytes, Mononuclear; Middle Aged; Interferon-gamma; Female; Male