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Dok-7/MuSK signaling and a congenital myasthenic syndrome.

Abstract:

Skeletal muscle contraction is controlled by motor neurons, which contact the muscle at the neuromuscular junction (NMJ). The formation and maintenance of the NMJ, which includes the aggregation of densely packed clusters of acetylcholine receptor (AChR) opposite the motor nerve terminal, is orchestrated by muscle-specific receptor tyrosine kinase, MuSK. Recently, a MuSK-interacting cytoplasmic adaptor-like protein Dok-7 was identified and its localization at the postsynaptic region of the NM...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience, Molecular Medicine
Role:
Author
Journal:
Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology / edited by the Gaetano Conte Academy for the study of striated muscle diseases
Volume:
27
Issue:
JULY
Pages:
25-29
Publication date:
2008-07-05
ISSN:
1128-2460
URN:
uuid:a9935e5c-6112-4c1d-8837-5b73e6a827e1
Source identifiers:
243321
Local pid:
pubs:243321

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