Dictyostelium discoideum: cellular self-organization in an excitable biological medium.

Journal article

The dynamics which govern the establishment of pattern and form in multicellular organisms remain a key problem of developmental biology. We study this question in the case of morphogenesis during aggregation of the slime mould Dictyostelium discoideum. Here detailed experimental information allows the formulation of a mechanistic model in which the central element is the coupling of the previously much-studied intracellular cyclic AMP signalling with the chemotactic cell response in cyclic A...

Expand abstract

Authors: Höfer, T; Sherratt, J; Maini, P

• Publication status: Published
• Journal: Proceedings. Biological sciences / The Royal Society
• Volume: 259
• Issue: 1356
• Pages: 249-257
• Publication date: 1995-03-01
• DOI: 10.1098/rspb.1995.0037
• EISSN: 1471-2954
• ISSN: 0962-8452
• Language: English
• Keywords: Chemotaxis; Cell Adhesion; Dictyostelium; Culture Media; Models, Biological; Cyclic AMP; Animals