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The importance of considering competing treatment affecting prognosis in the evaluation of therapy in trials: the example of renal transplantation in hemodialysis trials.

Abstract:

Background: During the follow-up in a randomized controlled trial (RCT), participants may receive additional (non-randomly allocated) treatment that affects the outcome. Typically such additional treatment is not taken into account in evaluation of the results. Two pivotal trials of the effects of hemodiafiltration (HDF) versus hemodialysis (HD) on mortality in patients with end-stage renal disease reported differing results. We set out to evaluate to what extent methods to take other treatm...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/ndt/gfw458

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Institution:
University of Oxford
Division:
MSD
Department:
Women's and Reproductive Health
Role:
Author
Publisher:
Oxford University Press Publisher's website
Journal:
Nephrology Dialysis Transplantation Journal website
Volume:
32
Issue:
S2
Pages:
ii31-ii39
Publication date:
2017-02-27
Acceptance date:
2016-12-20
DOI:
EISSN:
1460-2385
ISSN:
0931-0509
Language:
English
Keywords:
Pubs id:
pubs:689331
UUID:
uuid:a9857cdb-7241-4973-ae00-af1a1fab9cf5
Local pid:
pubs:689331
Source identifiers:
689331
Deposit date:
2017-08-11

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