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Journal article

Targets of antibodies against Plasmodium falciparum-infected erythrocytes in malaria immunity.

Abstract:

Plasmodium falciparum is the major cause of malaria globally and is transmitted by mosquitoes. During parasitic development, P. falciparum-infected erythrocytes (P. falciparum-IEs) express multiple polymorphic proteins known as variant surface antigens (VSAs), including the P. falciparum erythrocyte membrane protein 1 (PfEMP1). VSA-specific antibodies are associated with protection from symptomatic and severe malaria. However, the importance of the different VSA targets of immunity to malaria...

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Publication status:
Published

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Publisher copy:
10.1172/jci62182

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Journal:
The Journal of clinical investigation
Volume:
122
Issue:
9
Pages:
3227-3238
Publication date:
2012-09-05
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
URN:
uuid:a981b7ad-d8f9-498f-bf9b-3fc819ef547b
Source identifiers:
344039
Local pid:
pubs:344039

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