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Journal article

Apj+ vessels drive tumor growth and represent a tractable therapeutic target

Abstract:

Identification of cellular surface markers that distinguish tumorous from normal vasculature is important for the development of tumor vessel-targeted therapy. Here, we show that Apj, a G protein-coupled receptor, is highly enriched in tumor endothelial cells but absent from most endothelial cells of adult tissues in homeostasis. By genetic targeting using Apj-CreER and Apj-DTRGFP-Luciferase, we demonstrated that hypoxia-VEGF signaling drives expansion of Apj+ tumor vessels and that targeting...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.celrep.2018.10.015

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Grant:
Strategic Priority Research Program XDB19000000
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Publisher:
Cell Press Publisher's website
Journal:
Cell Reports Journal website
Volume:
25
Issue:
5
Pages:
1241-1254
Publication date:
2018-10-30
Acceptance date:
2018-10-03
DOI:
ISSN:
2211-1247
Pubs id:
pubs:927392
URN:
uri:a9817215-afe4-47eb-a7ff-98b1311408e0
UUID:
uuid:a9817215-afe4-47eb-a7ff-98b1311408e0
Local pid:
pubs:927392

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