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Single dose phenobarbitone prevents convulsions in cerebral malaria.

Abstract:
48 patients over 6 years of age with strictly defined cerebral malaria were randomised to receive either a single intramuscular injection of phenobarbitone (3.5 mg/kg) or placebo in a double-blind, placebo-controlled study. Phenobarbitone significantly reduced the incidence of subsequent convulsions from 54% to 12.5%, without adverse effects. A single intramuscular injection of phenobarbitone is a simple, cheap, and effective method for prevention of convulsions in cerebral malaria.
Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Journal:
Lancet
Volume:
2
Issue:
8602
Pages:
64-66
Publication date:
1988-07-01
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
Source identifiers:
17508
Language:
English
Keywords:
Pubs id:
pubs:17508
UUID:
uuid:a977b44f-57d7-4ead-9533-00c2f9cb2ad2
Local pid:
pubs:17508
Deposit date:
2012-12-19

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