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Thesis

Study of ceramide glucosyltransferase

Subtitle:
mechanism of inhibition by iminosugars
Abstract:

Ceramide glucosyltransferase (CGT) is a key enzyme in glycosphingolipid (GSL) biosynthesis in eukaryotic cells. Inhibition of enzyme activity by an N-alkylated imino sugar, N-butyl-deoxynojirimycin (NB-DNJ), has been evaluated for the therapeutic treatment of inherited glycosphingolipid lysosomal storage diseases. To develop more selective drugs for potential clinical use, further investigation of possible side effects and the design of a more selective inhibitor is requ...

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Institution:
University of Oxford
Department:
Life and Environmental Sciences Division
Role:
Author

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Role:
Supervisor
Role:
Supervisor
Publication date:
2001
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Barcode:
603861043
URN:
uuid:a96eb6ad-9058-485f-91c3-d7cde9762e81
Local pid:
td:603861043
Language:
English
Subjects:

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