- Subtitle:
- mechanism of inhibition by iminosugars
- Abstract:
-
Ceramide glucosyltransferase (CGT) is a key enzyme in glycosphingolipid (GSL) biosynthesis in eukaryotic cells. Inhibition of enzyme activity by an N-alkylated imino sugar, N-butyl-deoxynojirimycin (NB-DNJ), has been evaluated for the therapeutic treatment of inherited glycosphingolipid lysosomal storage diseases. To develop more selective drugs for potential clinical use, further investigation of possible side effects and the design of a more selective inhibitor is requ...
Expand abstract - Publication date:
- 2001
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- URN:
-
uuid:a96eb6ad-9058-485f-91c3-d7cde9762e81
- Local pid:
- td:603861043
- Language:
- English
- Subjects:
- Copyright holder:
- Narita, Keishi
- Copyright date:
- 2001
- Notes:
- This thesis was digitised thanks to the generosity of Dr Leonard Polonsky
Thesis
Study of ceramide glucosyltransferase
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