Thesis
Study of ceramide glucosyltransferase
- Alternative title:
- mechanism of inhibition by iminosugars
- Abstract:
-
Ceramide glucosyltransferase (CGT) is a key enzyme in glycosphingolipid (GSL) biosynthesis in eukaryotic cells. Inhibition of enzyme activity by an N-alkylated imino sugar, N-butyl-deoxynojirimycin (NB-DNJ), has been evaluated for the therapeutic treatment of inherited glycosphingolipid lysosomal storage diseases. To develop more selective drugs for potential clinical use, further investigation of possible side effects and the design of a more selective inhibitor is requ...
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Bibliographic Details
- Publication date:
- 2001
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Source identifiers:
-
603861043
Item Description
- Language:
- English
- Subjects:
- UUID:
-
uuid:a96eb6ad-9058-485f-91c3-d7cde9762e81
- Local pid:
- td:603861043
- Deposit date:
- 2014-10-14
Terms of use
- Copyright holder:
- Narita, Keishi
- Copyright date:
- 2001
- Notes:
- This thesis was digitised thanks to the generosity of Dr Leonard Polonsky
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