Back to Search

Journal article

A generalized model of mutation-selection balance with applications to aging

Abstract:: A probability model is presented for the dynamics of mutation-selection balance in a haploid infinite-population infinite-sites setting sufficiently general to cover mutation-driven changes in full age-specific demographic schedules. The model accommodates epistatic as well as additive selective costs. Closed form characterizations are obtained for solutions in finite time, along with proofs of convergence to stationary distributions and a proof of the uniqueness of solutions in a restricted ...
Expand abstract
Collapse abstract

Publication status:: Published

Actions

Email

Email this record

Send the bibliographic details of this record to your email address.

Your Email
Please enter the email address that the record information will be sent to.

-
Your message (optional)
Please add any additional information to be included within the email.
Cite

Cite this record

APA Style

Steinsaltz, D., Evans, S. N., & Wachter, K. (2004). A generalized model of mutation-selection balance with applications to aging. ADVANCES IN APPLIED MATHEMATICS, 35(1), 16–33.

MLA Style

Steinsaltz, D., et al. “A Generalized Model of Mutation-Selection Balance with Applications To Aging.” ADVANCES IN APPLIED MATHEMATICS, vol. 35, no. 1, 2004, pp. 16–33.

Chicago Style

Steinsaltz, D, SN Evans, and K Wachter. 2004. “A Generalized Model of Mutation-Selection Balance with Applications To Aging.” ADVANCES IN APPLIED MATHEMATICS 35 (1): 16–33.
Tweet
Print

Access Document

Publisher copy:: 10.1016/j.aam.2004.09.003

Authors

+ Steinsaltz, D More by this author

Institution:

University of Oxford

Division:

MPLS

Department:

Statistics

Role:

Author

+ Evans, SN More by this author

Role:

Author

+ Wachter, K More by this author

Role:

Author

Bibliographic Details

Journal:: ADVANCES IN APPLIED MATHEMATICS
Volume:: 35
Issue:: 1
Pages:: 16-33
Publication date:: 2004-03-01
DOI:: 10.1016/j.aam.2004.09.003
ISSN:: 0196-8858

Item Description

Language:: English
Keywords:: math.PR

q-bio.PE
Pubs id:: pubs:97778
UUID:: uuid:a96e5f82-c316-4551-9155-0e70740ee16e
Local pid:: pubs:97778
Source identifiers:: 97778
Deposit date:: 2012-12-19

Terms of use

Copyright date:: 2004
Notes:: 20 pages Updated to include more historical comment and references to
the literature, as well as to make clear how our non-linear, non-Markovian
model differs from previous linear, Markovian particle system and
measure-valued diffusion models. Further updated to take into account
referee's comments

Licence:: Terms and Conditions of Use for Oxford University Research Archive

Metrics

Views and Downloads

About views and downloads

If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP