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A model of oscillatory blood cell counts in chronic myelogenous leukaemia.

Abstract:

In certain blood diseases, oscillations are found in blood cell counts. Particularly, such oscillations are sometimes found in chronic myelogenous leukaemia, and then occur in all the derived blood cell types: red blood cells, white blood cells, and platelets. It has been suggested that such oscillations arise because of an instability in the pluri-potential stem cell population, associated with its regulatory control system. In this paper, we consider how such oscillations can arise in a mod...

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Publication status:
Published

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Publisher copy:
10.1007/s11538-011-9656-2

Authors


Journal:
Bulletin of mathematical biology
Volume:
73
Issue:
12
Pages:
2983-3007
Publication date:
2011-12-05
DOI:
EISSN:
1522-9602
ISSN:
0092-8240
URN:
uuid:a96badc4-b6a7-4542-96f7-e0b27567a921
Source identifiers:
202919
Local pid:
pubs:202919

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