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Synthesis of (-)-hygromycin A: application of Mitsunobu glycosylation and tethered aminohydroxylation.

Abstract:
Key points in the synthesis of (-)-hygromycin A are the tethered aminohydroxylation reaction used to prepare the aminocyclitol unit and the choice of a bulky protecting group on the sugar unit to facilitate selective Mitsunobu glycosylation and also bestow kinetic stability upon an otherwise vulnerable proton. © 2009 Wiley-VCH Verlag GmbH and Co. KCaA.
Publication status:
Published

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Publisher copy:
10.1002/anie.200902840

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Angewandte Chemie (International ed. in English) More from this journal
Volume:
48
Issue:
35
Pages:
6507-6510
Publication date:
2009-01-01
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
Language:
English
Keywords:
Pubs id:
pubs:34817
UUID:
uuid:a96832a9-f90e-43dc-a5d8-02525b8fce65
Local pid:
pubs:34817
Source identifiers:
34817
Deposit date:
2012-12-19

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