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Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21.

Abstract:

The 40-fold increase in childhood megakaryocyte-erythroid and B-cell leukemia in Down syndrome implicates trisomy 21 (T21) in perturbing fetal hematopoiesis. Here, we show that compared with primary disomic controls, primary T21 fetal liver (FL) hematopoietic stem cells (HSC) and megakaryocyte-erythroid progenitors are markedly increased, whereas granulocyte-macrophage progenitors are reduced. Commensurately, HSC and megakaryocyte-erythroid progenitors show higher clonogenicity, with increase...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.1211405109

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Statistics
Role:
Author
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Grant:
Specialist Programme Award 08030
Imperial College Biomedical Research Centre More from this funder
Medical Research Council More from this funder
National Institute for Health Research Oxford Biomedical Research Centre More from this funder
Kay Kendall Leukaemia Fund More from this funder
Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences of the United States of America Journal website
Volume:
109
Issue:
43
Pages:
17579-17584
Publication date:
2012-01-01
Acceptance date:
2012-09-17
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Source identifiers:
354088
Language:
English
Keywords:
Pubs id:
pubs:354088
UUID:
uuid:a966c292-f956-4b0b-9172-20e7394936c9
Local pid:
pubs:354088
Deposit date:
2013-11-16

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