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Exploitation of an iron transporter for bacterial protein antibiotic import.

Abstract:

Unlike their descendants, mitochondria and plastids, bacteria do not have dedicated protein import systems. However, paradoxically, import of protein bacteriocins, the mechanisms of which are poorly understood, underpins competition among pathogenic and commensal bacteria alike. Here, using X-ray crystallography, isothermal titration calorimetry, confocal fluorescence microscopy, and in vivo photoactivatable cross-linking of stalled translocation intermediates, we demonstrate how the iron tra...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1073/pnas.1713741114

Authors


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Role:
Author
ORCID:
0000-0001-7536-4552
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
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Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
114
Issue:
45
Pages:
12051-12056
Publication date:
2017-10-25
Acceptance date:
2017-09-28
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pubs id:
pubs:742106
URN:
uri:a95b72cc-1248-479c-b71c-ae6affcbb9b5
UUID:
uuid:a95b72cc-1248-479c-b71c-ae6affcbb9b5
Local pid:
pubs:742106

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