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Distinct kinetics of cytokine production and cytolysis in effector and memory T cells after viral infection.

Abstract:

In the present study, naive T cells were compared with in vivo generated effector and memory T cells expressing the same TCR specific for lymphocytic choriomeningitis virus. Upon restimulation in vitro, the same minimal concentrations of the full agonist peptide p33 and also of weak and partial agonist peptides were required for proliferation of naive, effector and memory T cells, indicating no difference in threshold of activation. However, activation kinetics were distinct. While effector c...

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Publication status:
Published

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Journal:
European journal of immunology More from this journal
Volume:
29
Issue:
1
Pages:
291-299
Publication date:
1999-01-01
DOI:
EISSN:
1521-4141
ISSN:
0014-2980

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