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Acute and sustained molecular changes in synovial fluid following acute knee injury mirror the murine joint injury response

Abstract:

Acute joint injury predisposes to OA, and is an ideal setting in which to study early disease pathogenesis. We have shown that an immediate inflammatory response occurs in connective tissues after injury, and a discrete group of mRNAs is up-regulated within hours of medial meniscal destabilisation (DMM) of the mouse joint. Some of this molecular response appears necessary for subsequent OA. We investigated a) whether these same molecules were up-regulated in the joint, and in the blood in the...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1016/j.joca.2014.02.035

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, KIR
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, KIR
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, KIR
Role:
Author
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Publisher:
Elsevier Publisher's website
Journal:
Osteoarthritis and Cartilage Journal website
Volume:
22
Pages:
S7-S8
Publication date:
2014-03-20
DOI:
EISSN:
1522-9653
ISSN:
1063-4584
URN:
uuid:a9583fb6-2c6c-47cc-88e7-8df103487644
Source identifiers:
466260
Local pid:
pubs:466260

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