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Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mapping

Abstract:

Structure-guided drug discovery emerged in the 1970s and 1980s, stimulated by the three-dimensional structures of protein targets that became available, mainly through X-ray crystal structure analysis, assisted by the development of synchrotron radiation sources. Structures of known drugs or inhibitors were used to guide the development of leads. The growth of high-throughput screening during the late 1980s and the early 1990s in the pharmaceutical industry of chemical libraries of hundreds o...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1098/rsta.2018.0422

Authors


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Name:
Cystic Fibrosis Trust
Grant:
Strategic Research Centre Awards 201
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Name:
Bill and Melinda Gates Foundation
Grant:
Shorten-TB Award
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Name:
Botnar Foundation
Grant:
6063
Publisher:
Royal Society
Journal:
Philosophical Transactions A: Mathematical, Physical and Engineering Sciences More from this journal
Volume:
377
Issue:
2147
Pages:
20180422
Publication date:
2019-04-29
Acceptance date:
2019-03-14
DOI:
EISSN:
1471-2962
ISSN:
1364-503X
Pmid:
31030650
Language:
English
Keywords:
Pubs id:
pubs:995625
UUID:
uuid:a957c5ae-66d6-41c4-a3fd-f9ff3ae25c2a
Local pid:
pubs:995625
Source identifiers:
995625
Deposit date:
2019-05-29

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