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Antibody to aquaporin 4 in the diagnosis of neuromyelitis optica.

Abstract:

BACKGROUND: Neuromyelitis optica (NMO) is a demyelinating disease of the central nervous system (CNS) of putative autoimmune aetiology. Early discrimination between multiple sclerosis (MS) and NMO is important, as optimum treatment for both diseases may differ considerably. Recently, using indirect immunofluorescence analysis, a new serum autoantibody (NMO-IgG) has been detected in NMO patients. The binding sites of this autoantibody were reported to colocalize with aquaporin 4 (AQP4) water ...

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Publisher copy:
10.1371/journal.pmed.0040133

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Journal:
PLoS medicine
Volume:
4
Issue:
4
Pages:
e133
Publication date:
2007-04-01
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
Source identifiers:
242101

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