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Discrimination of prostate cancer from benign disease by plasma measurement of intact, free prostate-specific antigen lacking an internal cleavage site at Lys145-Lys146.

Abstract:

BACKGROUND: The proportion of free prostate-specific antigen (PSA) is higher in the sera of patients with benign prostatic hyperplasia compared with patients with prostate cancer (PCa). We developed an immunoassay that measures intact, free PSA forms (fPSA-I), but does not detect free PSA that has been internally cleaved at Lys145-Lys146 (fPSA-N), and investigated whether this form could discriminate patients with PCa from those without PCa. METHODS: The assay for fPSA-I uses a novel monoclon...

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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Role:
Author
Journal:
Clinical chemistry
Volume:
47
Issue:
8
Pages:
1415-1423
Publication date:
2001-08-05
EISSN:
1530-8561
ISSN:
0009-9147
URN:
uuid:a952ce76-09a5-44ad-8778-7bab20f1d3e6
Source identifiers:
366034
Local pid:
pubs:366034

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