Journal article
Docking study and biological evaluation of pyrrolidine-based iminosugars as pharmacological chaperones for Gaucher disease
- Abstract:
-
We report on the synthesis and biological evaluation of a series of α-1-C-alkylated 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) derivatives as pharmacological chaperones for Gaucher disease. The parent compound, DAB, did not show inhibition of human β-glucocerebrosidase but showed moderate intestinal α-glucosidase inhibition; in contrast, extension of α-1-C-alkyl chain length gave a series of highly potent and selective inhibitors of the β-glucocerebrosidase. Our design of α-1-C-tridecyl-DAB (5j...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1039/c5ob02223a
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Authors
Bibliographic Details
- Publisher:
- Royal Society of Chemistry Publisher's website
- Journal:
- Organic and Biomolecular Chemistry Journal website
- Volume:
- 14
- Issue:
- 3
- Pages:
- 1039-1048
- Publication date:
- 2016-01-04
- Acceptance date:
- 2015-11-26
- DOI:
- EISSN:
-
1477-0539
- ISSN:
-
1477-0520
- URN:
-
uuid:a950c25a-e5fb-4dd9-b529-48b90c9fd73b
- Source identifiers:
-
598344
- Local pid:
- pubs:598344
- Paper number:
- 3
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright holder:
- The Royal Society of Chemistry
- Copyright date:
- 2016
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