Journal article icon

Journal article

Docking study and biological evaluation of pyrrolidine-based iminosugars as pharmacological chaperones for Gaucher disease

Abstract:

We report on the synthesis and biological evaluation of a series of α-1-C-alkylated 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) derivatives as pharmacological chaperones for Gaucher disease. The parent compound, DAB, did not show inhibition of human β-glucocerebrosidase but showed moderate intestinal α-glucosidase inhibition; in contrast, extension of α-1-C-alkyl chain length gave a series of highly potent and selective inhibitors of the β-glucocerebrosidase. Our design of α-1-C-tridecyl-DAB (5j...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Publisher copy:
10.1039/c5ob02223a

Authors


Nakagome, I More by this author
Yamamoto, A More by this author
Expand authors...
Publisher:
Royal Society of Chemistry Publisher's website
Journal:
Organic and Biomolecular Chemistry Journal website
Volume:
14
Issue:
3
Pages:
1039-1048
Publication date:
2016-01-04
Acceptance date:
2015-11-26
DOI:
EISSN:
1477-0539
ISSN:
1477-0520
URN:
uuid:a950c25a-e5fb-4dd9-b529-48b90c9fd73b
Source identifiers:
598344
Local pid:
pubs:598344
Language:
English
Keywords:

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP