Isw1 chromatin remodeling ATPase coordinates transcription elongation and termination by RNA polymerase II.

Journal article

We demonstrate that distinct forms of the yeast chromatin-remodeling enzyme Isw1p sequentially regulate each stage of the transcription cycle. The Isw1a complex (Iswlp/Ioc3p) represses gene expression at initiation through specific positioning of a promoter proximal dinucleosome, whereas the Isw1b complex (Iswlp/Ioc2p/Ioc4p) acts within coding regions to control the amount of RNA polymerase (RNAPII) released into productive elongation and to coordinate elongation with termination and pre-mRNA...

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Authors: Morillon, A; Karabetsou, N; O'Sullivan, J; Kent, N; Proudfoot, N

• Publication status: Published
• Journal: Cell
• Volume: 115
• Issue: 4
• Pages: 425-435
• Publication date: 2003-11-01
• DOI: 10.1016/s0092-8674(03)00880-8
• EISSN: 1097-4172
• ISSN: 0092-8674
• Language: English
• Keywords: Methylation; Repressor Proteins; Phosphorylation; Transcription, Genetic; Adenosine Triphosphatases; DNA-Binding Proteins; RNA Polymerase II; Chromatin Assembly and Disassembly; Saccharomyces cerevisiae Proteins; Gene Silencing; Nuclear Proteins; Phosphoserine; Nucleosomes; Transcriptional Elongation Factors; Genes, Fungal; Histones; Protein Conformation; Saccharomyces cerevisiae; Gene Expression Regulation, Fungal