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Journal article

Kinetic and crystallographic analysis of complexes formed between elastase and peptides from beta-casein.

Abstract:

Human beta-casomorphin-7 (NH2-Tyr-Pro-Phe-Val-Glu-Pro-Ile-CO2H) is a naturally occurring peptide inhibitor of elastase that has been shown to form an acyl-enzyme complex stable enough for X-ray crystallographic analysis at pH 5. To investigate the importance of the N-terminal residues of the beta-casomorphin-7 peptide for the inhibition of elastase, kinetic and crystallographic analyses were undertaken to identify the minimum number of residues required for effective formation of a stable com...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
European journal of biochemistry / FEBS
Volume:
268
Issue:
10
Pages:
2969-2974
Publication date:
2001-05-01
DOI:
EISSN:
1432-1033
ISSN:
0014-2956
Source identifiers:
31879
Language:
English
Keywords:
Pubs id:
pubs:31879
UUID:
uuid:a949e211-a464-4b53-98c6-e5c139baf9eb
Local pid:
pubs:31879
Deposit date:
2012-12-19

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