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Journal article

Structural and Biochemical Characterization of Rm3, a SubClass B3 Metallo-β-Lactamase Identified from a Functional Metagenomic Study.

Abstract:

β-Lactamase production increasingly threatens the effectiveness of β-lactams, which remain a mainstay of antimicrobial chemotherapy. New activities emerge both through mutation of previously known β-lactamases and mobilization from environmental reservoirs. The spread of metallo-β-lactamases (MBLs) represents a particular challenge through their typically broad spectrum activities, encompassing carbapenems in addition to other β-lactam classes. Increasingly, genomic and metagenomic studies re...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/AAC.00750-16

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More from this funder
Name:
European Regional Development Fund
Funding agency for:
Zhang, L
Wellington, E
Gaze, W
Grant:
500020
500020
500020
More from this funder
Name:
US National Institute of Allergy and Infectious Diseases
Funding agency for:
Hinchliffe, P
Spencer, J
Grant:
R01AI100560
R01AI100560
More from this funder
Name:
Natural Environment Research Council
Funding agency for:
Zhang, L
Wellington, E
Gaze, W
Grant:
500020
500020
500020
More from this funder
Name:
Medical Research Council
Funding agency for:
Salimraj, R
Brem, J
Schofield, C
Spencer, J
Grant:
U.K.-Canada Team Grant G1100135
U.K.-Canada Team Grant G1100135
U.K.-Canada Team Grant G1100135
R01AI100560
Publisher:
American Society for Microbiology
Journal:
Antimicrobial Agents and Chemotherapy More from this journal
Volume:
60
Issue:
10
Pages:
5828-5840
Publication date:
2016-07-18
Acceptance date:
2016-07-09
DOI:
ISSN:
0066-4804 and 1098-6596
Language:
English
Keywords:
Pubs id:
pubs:635551
UUID:
uuid:a94786fe-8d70-409f-8f46-96dda87c0163
Local pid:
pubs:635551
Source identifiers:
635551
Deposit date:
2016-08-08

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