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Journal article

Variation at HLA-DRB1 is associated with resistance to enteric fever

Abstract:

Enteric fever affects more than 25 million people annually and results from systemic infection with Salmonella enterica serovar Typhi or Paratyphi pathovars A, B or C1. We conducted a genome-wide association study of 432 individuals with blood culture–confirmed enteric fever and 2,011 controls from Vietnam. We observed strong association at rs7765379 (odds ratio (OR) for the minor allele = 0.18, P = 4.5 × 10−10), a marker mapping to the HLA class II region, in ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ng.3143

Authors


Publisher:
Springer Nature
Journal:
Nature Genetics More from this journal
Volume:
46
Issue:
12
Pages:
1333–1336
Publication date:
2014-11-10
Acceptance date:
2014-10-15
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Pmid:
25383971
Language:
English
Keywords:
Pubs id:
pubs:519661
UUID:
uuid:a9448311-7969-44b2-b6da-2ba445fa6b61
Local pid:
pubs:519661
Source identifiers:
519661
Deposit date:
2017-02-22

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