An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.

Journal article

Placental development and genomic imprinting coevolved with parental conflict over resource distribution to mammalian offspring. The imprinted genes IGF2 and IGF2R code for the growth promoter insulin-like growth factor 2 (IGF2) and its inhibitor, mannose 6-phosphate (M6P)/IGF2 receptor (IGF2R), respectively. M6P/IGF2R of birds and fish do not recognize IGF2. In monotremes, which lack imprinting, IGF2 specifically bound M6P/IGF2R via a hydrophobic CD loop. We show that the DNA coding the CD l...

Expand abstract

Authors: Williams, C; Hoppe, H; Rezgui, D; Strickland, M; Forbes, B

• Publication status: Published
• Journal: Science (New York, N.Y.)
• Volume: 338
• Issue: 6111
• Pages: 1209-1213
• Publication date: 2012-11-01
• DOI: 10.1126/science.1228633
• EISSN: 1095-9203
• ISSN: 0036-8075
• Language: English
• Keywords: Amino Acid Sequence; Alternative Splicing; Binding Sites; Receptor, IGF Type 2; Protein Structure, Tertiary; Insulin-Like Growth Factor II; Genomic Imprinting; Species Specificity; Enhancer Elements, Genetic; Evolution, Molecular; Exons; Animals; Conserved Sequence; Humans; Phylogeny; Molecular Sequence Data