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Oral Amoxicillin versus Benzyl Penicillin for Severe Pneumonia among Kenyan Children: A Pragmatic Randomized Controlled Non-inferiority Trial.

Abstract:

BACKGROUND:  There are concerns that the evidence from studies showing non-inferiority of oral amoxicillin to benzyl penicillin for severe pneumonia may not be generalizable to high mortality settings. METHODS:  An open-label multicenter randomized controlled non-inferiority trial was conducted at six Kenyan hospitals. Eligible children aged 2 - 59 months were randomized to receive amoxicillin or benzyl penicillin and followed up for the primary outcome of treatment failure at 48 hours. A non...

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Publisher copy:
10.1093/cid/ciu1166

Authors


Gathara, D More by this author
Edwards, T More by this author
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Journal:
Clin Infect Dis
Publication date:
2014-12-30
DOI:
EISSN:
1537-6591
URN:
uuid:a93d431d-5a6b-4bfb-bc67-7ce684144c64
Source identifiers:
502163
Local pid:
pubs:502163
Language:
English

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