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Journal article

Hydroxylation of methylated CpG dinucleotides reverses stabilisation of DNA duplexes by cytosine 5-methylation.

Abstract:
Cytosine-5-methylation stabilises DNA duplexes and is associated with transcriptional repression; 5-methylcytosine undergoes hydroxylation to 5-hydroxymethylcytosine, a modification of unknown biological function. Spectroscopic and calorimetric analyses show that 5-hydroxymethylcytosine introduction reverses the stabilising effect of 5-methylcytosine, suggesting that in some contexts, 5-methylcytosine hydroxylation may, along with other factors, contribute to the alleviation of transcriptional repression.
Publication status:
Published

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Publisher copy:
10.1039/c0cc05671e

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Chemical Communications
Volume:
47
Issue:
18
Pages:
5325-5327
Publication date:
2011-05-01
DOI:
EISSN:
1364-548X
ISSN:
1359-7345
Source identifiers:
127218
Language:
English
Keywords:
Pubs id:
pubs:127218
UUID:
uuid:a9376386-0613-4969-bb2c-7c97bcbc1b33
Local pid:
pubs:127218
Deposit date:
2012-12-19

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