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Hydroxylation of methylated CpG dinucleotides reverses stabilisation of DNA duplexes by cytosine 5-methylation.

Abstract:
Cytosine-5-methylation stabilises DNA duplexes and is associated with transcriptional repression; 5-methylcytosine undergoes hydroxylation to 5-hydroxymethylcytosine, a modification of unknown biological function. Spectroscopic and calorimetric analyses show that 5-hydroxymethylcytosine introduction reverses the stabilising effect of 5-methylcytosine, suggesting that in some contexts, 5-methylcytosine hydroxylation may, along with other factors, contribute to the alleviation of transcriptional repression.
Publication status:
Published

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Publisher copy:
10.1039/c0cc05671e

Authors


Thalhammer, A More by this author
Hansen, AS More by this author
El-Sagheer, AH More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Journal:
Chemical communications (Cambridge, England)
Volume:
47
Issue:
18
Pages:
5325-5327
Publication date:
2011-05-05
DOI:
EISSN:
1364-548X
ISSN:
1359-7345
URN:
uuid:a9376386-0613-4969-bb2c-7c97bcbc1b33
Source identifiers:
127218
Local pid:
pubs:127218

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