- Abstract:
-
Late-phase clinical trials investigating metformin as a cancer therapy are underway. However, there remains controversy as to the mode of action of metformin in tumors at clinical doses. We conducted a clinical study integrating measurement of markers of systemic metabolism, dynamic FDG-PET-CT, transcriptomics, and metabolomics at paired time points to profile the bioactivity of metformin in primary breast cancer. We show metformin reduces the levels of mitochondrial metabolites, activates mu...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 4.0mb)
-
- Publisher copy:
- 10.1016/j.cmet.2018.08.021
-
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- Publisher:
- Cell Press Publisher's website
- Journal:
- Cell Metabolism Journal website
- Volume:
- 28
- Issue:
- 5
- Pages:
- 679-688.e4
- Publication date:
- 2018-09-20
- Acceptance date:
- 2018-08-24
- DOI:
- ISSN:
-
1550-4131
- Pubs id:
-
pubs:864243
- URN:
-
uri:a9320331-ae91-42bb-bc6d-1fcd4384e020
- UUID:
-
uuid:a9320331-ae91-42bb-bc6d-1fcd4384e020
- Local pid:
- pubs:864243
- Language:
- English
- Keywords:
- Copyright holder:
- Crown Copyright
- Copyright date:
- 2018
- Notes:
-
Crown Copyright © 2018 Published by Elsevier Inc.
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Journal article
Integrated pharmacodynamic analysis identifies two metabolic adaption pathways to metformin in breast cancer
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Funding
Engineering and Physical Sciences Research Council
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NIHR Oxford Biomedical Research Centre
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Breast Cancer Research Foundation
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