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Biallelic ATM inactivation significantly reduces survival in patients treated on the United Kingdom Leukemia Research Fund Chronic Lymphocytic Leukemia 4 trial.

Abstract:

PURPOSE: The prognostic significance of ATM mutations in chronic lymphocytic leukemia (CLL) is unclear. We assessed their impact in the context of a prospective randomized trial. PATIENTS AND METHODS: We analyzed the ATM gene in 224 patients treated on the Leukemia Research Fund Chronic Lymphocytic Leukemia 4 (LRF-CLL4) trial with chlorambucil or fludarabine with and without cyclophosphamide. ATM status was analyzed by denaturing high-performance liquid chromatography and was related to treat...

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Publication status:
Published

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Publisher copy:
10.1200/jco.2011.41.0852

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Journal:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology More from this journal
Volume:
30
Issue:
36
Pages:
4524-4532
Publication date:
2012-12-01
DOI:
EISSN:
1527-7755
ISSN:
0732-183X

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